NMN may supplement NAD+ levels in the aging brain

In a new study published in the journal NPJ Aging, UW researchers used a new method to accurately measure NAD+ levels in the hypothalamus of young and old mice[1].

Imai and colleagues found that NAD+ levels decreased significantly in three of four measured subregions of the hypothalamus. Correspondingly, a single dose of 300 mg/kg NMN injected into 22-month-old mice restored NAD+ levels in all three regions. In addition, the researchers found that injecting aged mice with vesicles containing the NAD+ synthase NAMPT increased NAD+ levels in the hypothalamus by nearly 50 percent.

NMN restores decreased NAD+ levels in the hypothalamus

Before this study, scientists lacked the technology to accurately measure NAD+ levels in small tissues. Because the hypothalamus is divided into extremely small subregions called nuclei, data on the role of NAD+ in hypothalamic aging are very limited. Using a new combinatorial approach to NAD+ measurements, Imai and colleagues succeeded in showing that NAD+ levels decreased in aged mice in three of the four measured subregions of the hypothalamus.

NAMPT-containing vesicles increase hypothalamic NAD+ levels

NAMPT is an NAD+ enhancer and longevity promoter in multiple tissues, and previous studies have shown that transplantation of small vesicles from young mice boosts NAD+ and extends lifespan in older mice. With this in mind, Imai and colleagues investigated whether transplantation of similar vesicles could exert NAD+ enhancing effects in the hypothalamus.

NMN and eNAMPT as potential therapeutic interventions in brain aging

As Imai and colleagues establish a new model to accurately quantify hypothalamic NAD+ levels, we can better monitor hypothalamic aging and potentially identify new therapeutic approaches. Our brains inevitably experience age-related declines in function from ongoing damage from continuous stressors such as inflammation and DNA damage, which rely on NAD+ for mitigation.

Therefore, finding ways to replenish NAD+ in multiple tissues is critical to inhibit aging and organ degeneration. The current findings show that NMN and eNAMPT successfully restore NAD+ levels in the aged hypothalamus, highlighting the potential for these treatments to improve aspects of brain aging such as poorer sleep quality, decreased physical function, and impaired cognition.

[1] Johnson, S., Yoshioka, K., Brace, C.S. et al. Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus. npj Aging 9, 1 (2023).

Tag: NMN

Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers