The role of NMN in research

Nicotinamide Mononucleotide (NMN) is an intermediate in the salvage synthetic pathway of nicotinamide adenine dinucleotide (NAD+) in mammals.

Oral administration of NMN can increase the expression of long-lived protein Sirtuins. On February 19, 2019, the mid-term report of the clinical trial "Effect of long-term (24 weeks) oral administration of NAD+ precursor NMN on human body" conducted by the Graduate School of Biopharmaceuticals and Health of Hiroshima University in Japan was first released . The report shows that after oral administration of NMN capsules, the expression of the Sirtuins family of longevity proteins increases.

From the increased expression of Sirtuins protein, it can be speculated that various senile diseases (such as common diseases of the elderly, cancer and dementia) can be improved or completely recovered by treatment. "The person in charge of Hiroshima University said, "In order to further carry out NMN research, future clinical research results will be announced to NMN research institutions and other clinical research institutions to further confirm the positive role of NMN in reversing aging.

1. Prevention of Alzheimer's disease

A hallmark of degenerative neurological disorders such as Alzheimer's disease (AD) is the impairment of mitochondrial function, therefore, another strategy to maintain cellular nad + h levels is to administer nad + h precursors such as NMN to promote production through a salvage pathway .

Experiments in which mice were injected with NMN for three consecutive months These experiments suggest that in transgenic mice expressing this mutation in vivo, the lack of NAD levels may play a role in mitochondrial respiratory dysfunction and can be corrected by adding NAD+. Reduced mitochondrial elongation and fragmentation were found to be effective in preventing Alzheimer's in NMN-treated animals.

2. Regulate diabetes and improve insulin function

The scenes seen in the animal experiments are very spectacular. Older mice given NAD+ precursor supplements became leaner, had better insulin sensitivity, and had younger stem cell function. Improve insulin sensitivity Many studies have shown that the intake of NMN can improve the insulin sensitivity of middle-aged and elderly people, even overweight or obese women who already have hyperglycemia.

3. Improve muscle function and prevent osteoporosis

Improving muscle function A study on elderly men reported that daily oral administration of 250mg of NMN can improve muscle function and can be used to prevent aging-related muscle dysfunction in humans. Studies have also shown that NMN increases the body's aerobic capacity during exercise training, and that this improvement may be the result of increased oxygen utilization by skeletal muscles.

4. Improve sleep

Improve sleep quality A randomized double-blind study of the elderly showed that taking NMN daily can improve the sleep quality and relieve fatigue of the elderly.

Tag: NMN

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