NMN reduces age-related weight gain in a dose-dependent manner - Knowledge

NMN reduces age-related weight gain in a dose-dependent manner

Apr 24, 2022 / Author: China Glutathione suppliers & NMN manufacturers

Obesity is a global health problem, and its prevalence is rising. The McKinsey Global Institute reported in 2014 that if current growth rates continue, nearly half of the world's adults will be overweight or obese by 2030.

NMN reduces age-related weight gain in a dose-dependent manner

NMN can reduce age-related weight gain in a dose-dependent manner and has been experimentally validated in that 100 mg/kg and 300 mg/kg doses of NMN, administered for 12 consecutive months, were able to reduce mice, respectively At 4% and 9% body weight, the mice showed no impairment in growth and appetite compared to controls.

There is an interconnection between the pathology of obesity and diabetes, obesity negatively affects health by altering biochemical pathways that lead to mitochondrial dysfunction, and liver mitochondria reduce ATP production through changes in NAD+ and NADH levels leading to insulin resistance and type 2 diabetes .

NMN reduces age-related weight gain in a dose-dependent manner

There are experiments comparing the therapeutic effects of NMN and 6-week exercise on obese mice through a high-fat diet (HFD) mouse model. In the experiment, oral NMN at a dose of 500 mg/kg for 17 days successfully increased the content of NAD+ in muscle and liver that was reduced by obesity, but exercise only increased the content of NAD+ in muscle; NMN treatment also improved metabolic disorders, such as glucose deficiency. Tolerance and reduction of hepatic citrate synthase activity results in greater changes in markers of mitochondrial function in the liver than in muscle, so NAD precursor therapy may be effective in treating obesity-related liver disease.

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