Several studies have shown that NMN interventions can improve diabetes status.

In our modern lifestyle, type 2 diabetes mellitus (T2DM) has become an epidemic. Diabetes mellitus is a metabolic disease characterized by hyperglycemia and is accompanied by many complications. It has become a dangerous disease after cancer.

Studies have found that NAD+ levels in the brains of diabetic patients are significantly reduced, prompting scholars to explore research on increasing NAD+ levels to prevent diabetes.

In order to study the pathophysiology of NMN treatment of diet and age-induced diabetes in mice, Yoshino et al. established a diabetic mouse model and selected spontaneously formed diabetic mice. Rapidly appeared in the plasma, liver, white adipose tissue, and pancreas of mice; then within 60 min, NMN was immediately used for NAD+ biosynthesis, resulting in a significant increase in NAD+ concentrations in the liver, indicating that NMN improved age-induced T2DM in mice and Glucose intolerance and lipid profiles in diet-induced mice without affecting glucose homeostasis in non-diabetic mice.

The results of Revollo et al. also proved that the improvement of glucose tolerance and insulin secretion in mice can be achieved by supplementing NMN. Chandrasekaran et al. established a diabetic rat model with STZ and obtained the same experimental results. Caton et al. showed that NMN can also increase the concentration of extracellular nicotinamide phosphoryltransferase by inhibiting IL-1β in islet cells, improve inflammation-mediated islet cell dysfunction, and restore insulin secretion from beta cells.

The above studies have shown that NMN intervention therapy can regulate the glucose metabolism, lower blood sugar and improve diabetes status in experimental animals.

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