S-Adenosyl-L-methionine(SAMe) is a common cosubstrate involved in methyl group transfers. SAMe was first discovered in Italy by G.
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S-Adenosyl-L-methionine(SAMe) is a common cosubstrate involved in methyl group transfers. SAMe was first discovered in Italy by G.L. Cantoni in 1952, SAMe is a molecule produced constantly by all living cells,can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis, s-adenosyl-l-methionine-tosylate disulfate is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday SAMe is commonly used in pharmaceuticals, health care food industry both at domestic and international market.
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In bacteria, S-Adenosyl-L-methionine is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, S-Adenosyl-L-methionine serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, S-Adenosyl-L-methionine is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule.
As of 2012 the evidence was inconclusive as to whether SAM can mitigate the pain of osteoarthritis; clinical trials that had been conducted were too small from which to generalize. A 2016 study concluded that for major depressive disorder, "Given the absence of high quality evidence and the inability to draw firm conclusions based on that evidence, the use of S-Adenosyl-L-methionine for the treatment of depression in adults should be investigated further.
The S-Adenosyl-L-methionine cycle has been closely tied to the liver since 1947 because people with alcoholic Cirrhosis of the liver would accumulate large amounts of methionine in their blood. While multiple lines of evidence from laboratory tests on cells and animal models suggest that SAM might be useful to treat various liver diseases, as of 2012 SAM had not been studied in any large randomized placebo-controlled clinical trials that would allow an assessment of its efficacy and safety.
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