Aug 15, 2023 / Author: China Glutathione suppliers & NMN manufacturers
In a new study published in the journal NPJ Aging, UW researchers used a new method to accurately measure NAD+ levels in the hypothalamus of young and old mice.
Imai and colleagues found that NAD+ levels decreased significantly in three of four measured subregions of the hypothalamus. Correspondingly, a single dose of 300 mg/kg NMN injected into 22-month-old mice restored NAD+ levels in all three regions. In addition, the researchers found that injecting aged mice with vesicles containing the NAD+ synthase NAMPT increased NAD+ levels in the hypothalamus by nearly 50 percent.
NMN restores decreased NAD+ levels in the hypothalamus
Before this study, scientists lacked the technology to accurately measure NAD+ levels in small tissues. Because the hypothalamus is divided into extremely small subregions called nuclei, data on the role of NAD+ in hypothalamic aging are very limited. Using a new combinatorial approach to NAD+ measurements, Imai and colleagues succeeded in showing that NAD+ levels decreased in aged mice in three of the four measured subregions of the hypothalamus.
NAMPT-containing vesicles increase hypothalamic NAD+ levels
NAMPT is an NAD+ enhancer and longevity promoter in multiple tissues, and previous studies have shown that transplantation of small vesicles from young mice boosts NAD+ and extends lifespan in older mice. With this in mind, Imai and colleagues investigated whether transplantation of similar vesicles could exert NAD+ enhancing effects in the hypothalamus.
NMN and eNAMPT as potential therapeutic interventions in brain aging
As Imai and colleagues establish a new model to accurately quantify hypothalamic NAD+ levels, we can better monitor hypothalamic aging and potentially identify new therapeutic approaches. Our brains inevitably experience age-related declines in function from ongoing damage from continuous stressors such as inflammation and DNA damage, which rely on NAD+ for mitigation.
Therefore, finding ways to replenish NAD+ in multiple tissues is critical to inhibit aging and organ degeneration. The current findings show that NMN and eNAMPT successfully restore NAD+ levels in the aged hypothalamus, highlighting the potential for these treatments to improve aspects of brain aging such as poorer sleep quality, decreased physical function, and impaired cognition.
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