The therapeutic effect of NMN on stroke

Stroke is an acute cerebrovascular disease caused by cerebral blood circulation disorder, which has high mortality and morbidity, and seriously threatens human health.

Studies have found that NMN can protect cranial nerves and promote blood vessel and nerve regeneration by activating the Nampt-NAD+ defense system, and has a good protective effect on nerve damage caused by cerebral hemorrhage and cerebral hemorrhage transformation.

By analyzing the metabolic process of NMN in brain tissue, Park et al. found that NMN prevents cerebral ischemia-induced neuronal apoptosis by improving the bioenergy metabolism of post-ischemic tissues and promotes nerve regeneration after cerebral ischemia. Bloody brain injury has a strong protective effect.

For hemorrhagic brain injury, increasing the level of NMN can reduce the hemoglobin content in infarcted tissue, reduce hemorrhage and edema, and reduce the oxidative toxicity damage of brain tissue caused by oxidative stress.

In addition, Chunchun Wei and his team further study showed that NMN enhanced the expression of two cytoprotective proteins, namely nuclear factor-erythroid 2 related factor 2 (Nrf2) and heme oxygenase (Heme oxygenase). , HO-1), activated the Nrf2/HO-1 signaling pathway, inhibited brain neuroinflammation and oxidative stress, and alleviated the injury after intracerebral hemorrhage.

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