Mar 18, 2021 / Author: China Glutathione suppliers & NMN manufacturers
L-carnosine (β-alanyl-L-histidine) and its analogs (such as homocarnosine and anserine) are naturally active dipeptides widely found in mammalian brains,L-Carnosine muscles and other important tissues. Since the discovery of the active peptide for more than one hundred years,L-Carnosine a large number of studies have found or proved that L-carnosine has significant anti-oxidation, elimination of intracellular free radicals,L-Carnosine anti-aging and other activities, and it is clinically used for hypertension and heart Adjuvant treatment of diseases,L-Carnosine senile cataracts, ulcers, anti-tumor, and promotion of wound healing. Because of its strong antioxidant activity,L-Carnosine low toxic and side effects and various physiological activities, the active peptide and its derivatives have been widely used in the fields of medicine,L-Carnosine health care, hygiene, cosmetics, etc., and the market space is broad.
At present,L-Carnosine the production of L-carnosine mainly uses chemical synthesis. There are many existing chemical synthesis methods,L-Carnosine which can be divided into two main categories: (1) Use β-alanine to participate in the synthesis. The main route is to condense β-alanine with protected L-histidine after amino protection and carboxyl activation,L-Carnosine and then remove the protective group to obtain L-carnosine. Due to the difference of each protecting group,L-Carnosine this route leads to more synthetic routes. The commonly used method is to use phthalic anhydride and β-alanine to generate phthaloyl-β-alanine to protect the amino group,L-Carnosine and the carboxyl group reacts with thionyl chloride to generate phthaloyl-β-alanine. The acid chloride forms a peptide bond with the protected L-histidine and then deprotects the group to obtain the product. This route is more complicated, the yield is low,L-Carnosine the peptide bond is easily racemized during the formation of the peptide bond, which affects the purity of the product, and the solvent consumption is large,L-Carnosine which is easy to cause environmental pollution;
Reaction without β-alanine: The main principle is that L-histidine first forms peptide bonds with different β-alanine precursors,L-Carnosine and then is further converted into carnosine. The commonly used route is under the action of sodium alkoxide, L-histidine and ethyl cyanoacetate undergo an acylation reaction to obtain cyanoacetyl-L-histidine,L-Carnosine which is reduced by catalytic hydrogenation to obtain L-carnosine. This route is relatively simple, omits the process of protecting and deprotecting different groups,L-Carnosine and avoids the occurrence of racemization reaction, but it requires anhydrous operation and strict requirements. At the same time,L-Carnosine ethyl cyanoacetate is an environmental toxic substance,L-Carnosine which is easy to cause water pollution and toxic reactions.
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers
Oct 20, 2023