NMN Safe And Effective Anti-aging

Nicotinamide Mononucleotide (NMN) is a kind of biologically active nucleotide, which is widely found in various foods, and the content in vegetables and fruits is more than 0.25~1.88 mg/ 100 g. NMN has become well known in recent years as a precursor in the synthesis of nicotinamide adenine dinucleotide (NAD+).

NAD+ is a key signaling molecule that controls cellular function and survival during environmental changes such as nutrient intake and cellular damage, as a variety of proteins including sirtuins (SIRTs) and adenosine polyphosphate ribose polymerases (PARPs) Family of key substrates that play important roles in the regulation of almost all major biological processes.

NAD+ levels gradually decline with age, resulting in decreased cell and organ function, metabolic changes and increased disease susceptibility. Delaying or reversing the decline in NAD+ can improve physiological and metabolic parameters such as muscle function, exercise capacity, and cardiac function.

Direct supplementation of therapeutic doses of NAD+ is prone to side effects such as insomnia, fatigue and anxiety, and its ability to penetrate through cell membranes is poor, while NMN supplementation can safely and effectively increase the body’s NAD+ levels.

NAD+ and its precursors have been shown to have certain potential in prolonging lifespan, and NMN can effectively delay the appearance of the progeria phenotype and prolong lifespan in nematode models; Fang et al. Improves mitochondrial mass and prolongs lifespan in ataxia telangiectasia model mice.

Many studies have also revealed that NMN can effectively treat aging-related diseases.

In in vitro experiments, NMN can improve the proliferation and migration of aging vascular endothelial cells; promote the osteogenic proliferation of aging mesenchymal stem cells, reduce adipogenesis, improve the fertilization ability of aging oocytes, restore mitochondrial function, and inhibit the induction of reactive oxygen species. apoptosis of senescent oocytes. In animal experiments, Mills et al. found that long-term administration of NMN improved mitochondrial energy metabolism, insulin sensitivity, plasma lipid profile, and eye function in aging mice.

Recently, studies have found that NMN can improve the metabolic level of aging mice to a certain extent, and its mechanism of action is likely to be related to the improvement of the body's antioxidant capacity. In another study in aged mice, NMN restored arterial SIRT1 activity and improved aging-related endothelial dysfunction. Guan et al. studied the effect of supplementing NMN on renal insufficiency in aging mice and found that NMN could restore the NAD+ content and SIRT1 activity in the kidney, regulate the JNK signaling pathway to attenuate the stress response, and thus protect the kidney from cisplatin-induced acute kidney injury. . NAD+ levels, NAMPT expression, and neural stem cell numbers were all reduced in the hippocampus of aged mice, and chronic NMN administration enhanced NAD+ levels and maintained neural stem cell numbers in the dentate gyrus. Furthermore, NMN reversed hearing loss in aged animals by increasing NAD+ levels and activating SIRT3.