5 Research Findings About the Efficacy of NMN

In the field of scientific research, the exploration of NMN has not stopped, and more and more new achievements have been discovered, constantly demonstrating its safe and good anti-aging, repairing and other important functions.

Let's take a look at the five major effects of NMN obtained from the latest research after a large number of animal experiments:

1. Protect the optic nerve and reduce retinal damage

Professor David Sinclair published an article in the top scientific journal "Aging", saying: NMN also has a good protective effect on the optic nerve, and can significantly inhibit the aggravation of retinal detachment and other diseases.

Prior to this, the scientific community believed that taking NMN to supplement NAD+ to restore it to a healthy state can protect nerves.

This time, Professor David Sinclair's research found that after supplementing NAD+ to a healthy level, additional supplementation is more conducive to improving the protective effect.

NMN may not be able to regenerate the depletion of CEC (corneal endothelial cells) cells that have occurred.

But taking NMN regularly can reduce possible future CEC damage and vision loss. It is especially useful for people who work outdoors or are often exposed to UVB rays, because long-term unprotected sun exposure can seriously damage the cornea.

Supplementing with NMN may be a wise choice for protecting your eyes from UVB damage.

2. Improve hair loss

Hair loss and hair graying are actually a natural phenomenon and a normal manifestation of human metabolism. Under normal circumstances, people will shed 50-100 hairs in the rest period every day, and there will be about the same amount of new hair. "Sprouting", and more than 100 hairs that fall out every day is considered alopecia.

Studies have shown that NADPH increases with age, and 5α-reductase (5α-reductase) is a membrane protease dependent on reduced coenzyme II (NADPH), one of its functions is to catalyze the conversion of testosterone into dihydrotestosterone (DHT) , and dihydrotestosterone is the culprit of male pattern baldness.

NADPH can reduce the production of dihydrotestosterone by transferring electrons to NAD+ to become NADH, but NAD+ decreases with age, resulting in a large amount of NADPH having no chance to become NADH. Therefore, with age and other external factors, the higher the level of dihydrotestosterone, the more severe the baldness.

On the other hand, as the age increases and the level of NAD+ decreases, the hair mother cells do not have enough ATP to synthesize hair protein, and eventually the hair mother cells lose their vitality, which will eventually lead to hair loss.

Scientists from Harvard Medical School and the team of Professor Ichiro Kanai of Japan have proved experimentally that after injecting the enzyme that synthesizes NMN in the blood of young mice into old mice, the hair becomes black and thick, and the effect is comparable to "hair transplantation".

And the research results were published in the authoritative academic journal "Cell" sub-journal "Cell".

Another human trial can prove more conclusively that NMN helps to improve hair loss.

At the 71st Korean Dermatology Congress, Professor Hang Cheol Shin from Soongsil University and others disclosed that they are developing a new hair growth technology.

Using microneedles, they implanted NMN with the growth factor cocktail Cellcurin™ into the scalps of 20 patients with androgenetic alopecia. After 3 months, these people had a very good improvement in hair volume and hair quality.

3. Slow down muscle aging and prolong health period

Aging is an unavoidable condition of increasing age. Muscle aging is one of the important reasons for the rapid decline in the quality of life and health of the middle-aged and elderly population.

On February 10, 2019, scientists discovered that NNMT was overexpressed with muscle aging, and adding its inhibitor prevented the reduction of NAD+, thereby reversing muscle aging.

In January 2021, Professor Johan Auwerx of Mitochondrial Research published an article stating that NAD+ supplementation can improve mitochondrial function in various animal models, delay muscle aging to a large extent, and thus prolong the healthy period.

This once again proves the efficacy of NAD+ in delaying aging.

4. Prevent Cardiovascular Diseases

In December 2020, JACC published an authoritative report on the global burden of cardiovascular disease and risk factors. The study assessed the health status of populations in 204 countries from 1990 to 2019.

The results showed that the number of patients with cardiovascular diseases increased from 271 million to 523 million, a growth rate of 92.99%; the number of deaths from cardiovascular diseases increased from 12.1 million to 18.6 million.

It can be concluded that the mortality rate of cardiovascular diseases in the world ranks first in the death of diseases, among which, the mortality rate of cardiovascular diseases in the Chinese population is the highest.

Recently, Dr. Liu Qiming, director of the Department of Cardiovascular Medicine at the Second Xiangya Hospital of Central South University, led a team to publish a review article in the famous international journal "Clinica Chimica Acta", comprehensively and in-depth review of the important role played by NAD+ in cardiovascular diseases.

Dr. Liu Qiming clearly stated in the article that supplementing and stabilizing the healthy level of NAD+ in the human body is currently one of the best ways to treat and even prevent cardiovascular diseases.

5. Repair Kidney Damage

In January 2021, several Italian medical experts published a review in the international scientific journal "Antioxidants & Redox Signaling", stating that a large number of experimental data in recent years have shown that supplementing NAD+ has a very good effect on repairing kidney damage.

Professor John Kellum, an expert in critical care medicine, also said that abnormal mitochondrial function and a sudden drop in NAD+ levels are one of the signs of kidney damage.

Therefore, supplementing NAD+ can help improve mitochondrial dysfunction, increase NAD+ levels, and repair kidney damage.

In December 2022, a study published by Tokushima University in Japan on Scientific Reports, by exploring the role of NMN and Sirtuin-1 (Sirt1) in focal segmental glomerulosclerosis (FSGS), once again proved that NMN can Effectively reduce kidney damage.

The researchers administered 500mg/kg/day of NMN to experimental mice and found that NMN restored a large number of cells (podocytes) that are critical to kidney waste filtration, increased the activity of the long-lived protein Sirt1, and reduced the damage associated with kidney tissue damage. Enzyme, relieves glomerulosclerosis.

Tag: NMN , hair loss, muscle aging

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