May 05, 2023 / Author: China Glutathione suppliers & NMN manufacturers
Citicoline is a neuroprotective compound that is a precursor to the neurotransmitter acetylcholine and other neuronal membrane components, acting as an intermediate in the synthesis of phosphatidylcholine.
A triad of biochemical and biological activities of citicoline on neurodegeneration:
1. Citicoline protects undamaged axons - neuroprotective activity (eg, reduces glutamate-induced neurotoxicity).
2. Citicoline rescues partially damaged neurons - neurorestorative activity (eg, membrane reintegration of damaged neurons).
3. Evidence from in vitro studies supports the ability of citicoline to regenerate neuronal cells—regenerative activity (eg, biosynthesis of structural components of cell membranes).
The effect of citicoline supplementation on CNS function has been studied in several neurodegenerative diseases. In Parkinson's disease, citicoline can reduce the side effects of levodopa, and has a rescue effect of levodopa, delaying the loss of efficacy.
There is evidence that citicoline has a positive effect on cognitive and behavioral impairment in elderly patients with cognitive impairment associated with chronic brain diseases such as Alzheimer's disease. It has been reported to have benefits in memory, reaction time, concentration, wakefulness, focus, behavior, overall central function, and general well-being. A systematic review of the Cochrane database identified 14 trials including 1051 patients with vascular cognitive impairment and Alzheimer's disease that demonstrated the positive effects of citicoline on memory and behaviour.
In ischemic stroke, several studies suggest that administration of citicoline, in addition to routine medical management of acute stroke, may improve brain function and reduce post-stroke cognitive decline, particularly producing better attention result.
Long-term administration of citicoline is safe and appears to promote neurogenesis and neurorepair, especially in older patients with less severe stroke who have not been treated with recombinant tissue plasminogen activator.
We supply high quality raw materials of Citicoline and Citicoline Sodium Salt, if you are interested in our products, please feel free to contact us, we will be happy to provide any information you need.
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers