The relationship between NMN and the liver - Knowledge

The relationship between NMN and the liver

Aug 04, 2023 / Author: China Glutathione suppliers & NMN manufacturers

The liver is a large metabolic organ in the human body. There are more than 700 kinds of human body reactions in the liver. It synthesizes protein, synthesizes glycogen to store energy, decomposes toxic substances that invade the human body from the outside, and stores 95% of vitamin A and other vitamins in the human body. The largest iron storage station in the world produces bile, a digestive juice that specifically dissolves fat.


Absorption of NMN in the liver

In 2011, the University of Washington in the United States cultured mouse liver cells in NMN, and mouse liver cells are similar to humans.

Experimental results show that liver cells can absorb NMN and convert it into NAD+ autonomously.

NMN and nonalcoholic liver disease

Non-alcoholic fatty liver disease (NAFLD) refers to non-alcoholic fatty liver disease that is not caused by alcohol damage, but by other factors that cause excessive fat deposition in liver cells, and eventually form non-alcoholic fatty liver disease. Obesity and insulin resistance are the two major causes of non-alcoholic fatty liver disease, and the prevalence of the disease is as high as 30% in developed regions of Europe and America and wealthy regions of China.

Non-alcoholic fatty liver disease can lead to liver cirrhosis, recurrence and metastasis of liver cancer cells, as well as type 2 diabetes and atherosclerosis.

a. Lack of NAD+ may cause non-alcoholic liver disease

In 2016, China's Second Military Medical University found that the lack of NAD+ in the human body is an important reason for non-alcoholic fatty liver disease in middle-aged and elderly people.

Experimental findings: 1. The older you get, the less NAD+ content in liver cells, and the NAD+ content in liver cells drops significantly after the age of 45. 2. Insulin resistance and liver fibrosis significantly increased in liver cells lacking NAD+, thus inducing non-alcoholic fatty liver disease.

b. NMN can alleviate non-alcoholic liver disease caused by NAD+ deficiency

At the end of the experiment, the scientists found that adding a NAD+ precursor supplement, NR (niacin), to the diet almost completely corrected steatosis and steatohepatitis in the mouse liver. However, NR (niacin) first synthesizes NMN in the human body, and then synthesizes NAD+, so directly supplementing NMN is a more effective method.

In the experiment, after the scientists fed the mice with high-fat food, the mice suffered from fatty liver and liver hypertrophy. Adding NAD+ prerequisite supplements to the high-fat diet significantly improved the fatty liver of the mice.

NMN and alcoholic liver disease

a. Alcoholic liver causes and harm

Alcoholic liver is a chronic liver disease caused by long-term heavy drinking. Initially, it usually presents as fatty liver, which can progress to alcoholic hepatitis, alcoholic fibrosis, and alcoholic cirrhosis. About 10 to 20 percent of alcoholics have varying degrees of alcoholic liver disease. Alcoholic liver disease may directly lead to cirrhosis, hepatic ascites, hepatic encephalopathy, liver cancer, and even hepatic coma and death.

b. NMN synthesizes NAD+ in the liver, soothes alcohol and protects the liver

After the human body ingests alcohol, its metabolic pathway is very complicated, but it is certain that 90% of alcohol must be metabolized by the liver, and long-term heavy drinking will cause a huge burden on the liver. The liver decomposes ethanol into acetaldehyde and then into acetic acid, and finally forms carbon dioxide and water to be excreted from the body. The whole process requires the participation of a large amount of NAD+. The content of NAD+ can directly affect the speed and efficiency of liver hangover. If the metabolism of alcohol is slow to produce alcohol poisoning, the accumulation of acetaldehyde will cause huge damage to the liver.

In 2018, the School of Biomedical Sciences of the University of Cambridge published a paper in the journal Nature. The paper showed that scientists found that the NAD+ content in mice was significantly restored on the second day after feeding NMN to mice with alcoholic liver disease, and NMN was effective Increases in markers of liver damage, alanine aminotransferase and aspartate aminotransferase, were prevented.

In 2019, scientists found through mouse gene sequencing experiments that ethanol can mutagenize 1778 genes in mice, and NMN can effectively protect 437 genes from ethanol attack. After the human body ingests alcohol, its metabolic pathway is very complicated, but it is certain that 90% of alcohol must be metabolized by the liver.

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