Citicoline Sodium (CDP-choline)

Citicoline sodium (CDP-choline) is an endogenous nucleoside naturally produced in the body. The repair of nerve cell membranes requires a large amount of Citicoline Sodium. It has the functions of repairing brain damage and anti-oxidation, and has been widely used in clinical.

In recent years, in addition to being used in brain surgery and traumatic brain injury, it is also used in the auxiliary treatment of function and consciousness, tremor paralysis, tinnitus, nervous deafness and amblyopia caused by acute injury of the central nervous system. Citicoline sodium is decomposed into choline and cytidine diphosphate (CDP) in the human body. The choline part is a good methylation donor in the body, which can transmethylate a variety of compounds and participate in various biochemical processes. Functions such as phosphatidylcholine (lecithin) are important building blocks of cells. The role of CDP is more extensive, and it can participate in lipid metabolism, high phosphorus nucleotide synthesis, and the conversion of intracellular biological messengers.

Therefore, citicoline sodium can promote the synthesis and reconstruction of damaged nerve biofilm, especially the metabolism of important components in the axon, and it can nourish the nerve, support the survival of damaged cells, and reduce the death of neurons. Injection of exogenous citicoline can promote the synthesis of phospholipids in nerve cell membranes.

The main advantages of citicoline as a neuroprotective compound are:

1. Negligible toxicity to humans and animals;

2. >90% bioavailability;

3. It can be administered intravenously, intramuscularly or orally;

4. After oral intake, citicoline sodium is metabolized into cytidine and choline in the systemic circulation, in which cytidine is converted into uridine, and both choline and uridine can pass through the blood-brain barrier.

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