Glutathione and adenosylmethionine protect liver health - Knowledge

Glutathione and adenosylmethionine protect liver health

Jul 29, 2025 / Author: China Glutathione suppliers & NMN manufacturers

The liver, as an important metabolic organ in the human body, undertakes many key functions such as detoxification, protein synthesis and energy storage. Its health is directly related to our overall quality of life.

On this significant day, GSH Bio-Tech also hopes to leverage its professional accumulation in the field of biology to popularize two important substances closely related to liver health for everyone - glutathione and adenosylmethionine.

Glutathione and adenosylmethionine protect liver health

Glutathione protects a healthy liver

Glutathione, one of the most common substances in the human body, is present in almost every cell in the body and is a natural active peptide with important physiological functions.

Glutathione is a tripeptide containing a γ -amide bond and a thiol group, composed of glutamic acid, cysteine and glycine. It is an important metabolic regulatory substance within cells and plays a significant role in maintaining the biological functions of cells.

The liver-protecting mechanism of glutathione is as follows:

1. Reduce oxidative damage

The liver is a major metabolic organ in the human body and also one of the main sites for the generation of free radicals and oxidative stress.

Glutathione, with its powerful antioxidant capacity, can neutralize reactive oxygen species (ROS) and free radicals, reducing the damage of oxidative stress to liver cells.

Glutathione Reduce oxidative damage

2. Neutralize and detoxify

The liver is the main organ for detoxification, and glutathione plays a key role in the liver's detoxification process.

3. Regulate enzyme activity

The liver is the main organ for alcohol detoxification in the human body. Glutathione indirectly regulates and repairs the activity of aldehyde dehydrogenase.

Adenosylmethionine protects a healthy liver

Adenosylmethionine, as A common auxiliary substrate involved in methyl transfer, can participate in over 40 biochemical reactions and is an active precursor of sulfur-containing compounds such as glutathione, cysteine, taurine and coenzyme A.

It has functions such as reducing liver damage, detoxifying, antioxidation, promoting liver cell regeneration, regulating emotions, and alleviating joint pain.

The three major mechanisms by which adenosylmethionine protects the liver are as follows:

1. Transalanine:

SAMe can increase the mitotic activity of hepatocytes through the action of transalanine, promote the regeneration of hepatocytes and the repair of damaged hepatocytes. Alleviate liver inflammation by inhibiting the expression of pro-inflammatory factors

2. Transmethylation

SAMe reduces the cholesterol/phospholipid ratio of liver cell membranes and red blood cell membranes through transmethylation, enhances the fluidity of cell membranes, and thereby improves the secretion and fluidity of bile.

Promote the synthesis of phosphatidylcholine: Maintain the integrity and function of cell membranes.

3. Transthiogenic:

SAMe promotes the synthesis of glutathione (GSH) through transthiol action, thereby enhancing the antioxidant and detoxification capabilities of liver cells.

References

  • Noureddin M,et al. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: 2020.

  • Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. 2007.

  • Hao X, Huang Y, Qiu M, et al. Immunoassay of S-adenosylmethionine and S-adenosylhomocysteine: the methylation index as a biomarker for disease and health status. 2016

Tag: Glutathione , adenosylmethionine

Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers

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