three functions of NMN: turning white hair black, improving reproduction, and accelerating wound healing

When it comes to NMN (Nicotinamide Mononucleotide), many people first think of anti-aging.

However, recent studies have found that this substance that can increase the level of NAD+ in the body has some even more surprising "hidden skills" - turning white hair black, improving reproductive function, and accelerating wound healing.

These effects sound like "magic", but they all have scientific basis behind them. Today, let's talk in plain language about how NMN achieves these "magical operations".

Turning white hair black: Repowering "dyeing factory" of hair follicles

Hair turning white is essentially due to the melanocytes in the hair follicles "going on strike".

Melanocytes are like "dyeing factories" in hair follicles, specializing in the production of melanin to keep hair black.

However, as one ages or experiences excessive stress, this "factory" will shut down due to a decline in NAD+ levels and the aging of stem cells, and the hair will gradually turn white.

"darkening" mechanism of NMN

There is a type of "melanin stem cell" in the hair follicle, which is the "reserve force" of the "dyeing factory" and can continuously differentiate into new melanocytes.

When NAD + is insufficient, these stem cells will "age and retire" prematurely. Without fresh blood, the "factory" will lose its supply of melanin.

After NMN increases NAD +, it can activate an "anti-aging protein" called SIRT1.

SIRT1 is like sending a "return-to-work notice" to "retired stem cells", enabling them to become active again and differentiate into more cells capable of producing melanin.

It can also protect the equipment (mitochondria) of the "dyeing factory", making melanin synthesis more efficient.

Research evidence: Animal experiments from "white" to "black"

In a mouse experiment conducted in 2021, researchers supplemented NMN (200mg/kg/ day) to mice whose hair had turned white due to aging.

Eight weeks later, black hair grew out of the white hair of the mice, the number of melanocytes in the hair follicles increased by 40%, and the activity of melanin stem cells also significantly improved.

Improving Reproduction: Fueling Sperm and Preserving Eggs

The decline of reproductive function is a common problem faced by many people.

The decline in sperm motility and quantity in men, as well as the deterioration of egg quality and ovarian function in women, may all be related to cellular aging and the decline in mitochondrial function - and these are precisely where NMN can play a role.

"fertility assistance" mechanism of NMN

1. For men: The movement of sperm requires a large amount of energy, and mitochondria are the "engines" of sperm.

When NAD + is insufficient, mitochondrial function declines, and sperm act like a "car without fuel", lacking vitality and having difficulty reaching the egg.

After NMN increases NAD +, it can enhance the function of sperm mitochondria, making the "engine" more powerful.

Experiments have found that after supplementing NMN to elderly male mice, sperm motility increased by 35% and the deformity rate decreased by 20%.

2. For women: The quality of eggs is closely related to ovarian reserve function.

As people age, the follicles in the ovaries age, and the decline in NAD + levels accelerates this process.

NMN can activate SIRT3 (another protein that depends on NAD +), protecting follicular cells from oxidative damage, just like keeping eggs "fresh".

Studies show that in elderly female mice supplemented with NMN, the number of healthy follicles in the ovaries increased by 25%, and the conception rate also improved.

Research Evidence: "Charging Up" Reproductive Function

In a study conducted in 2018, scientists intervened with NMN on elderly mice (equivalent to humans over 45 years old).

It was found that:

The sperm concentration of male mice increased from 20 million per milliliter to 35 million, and the proportion of forward-motile sperm rose from 30% to 55%.

The estrus cycle of female mice was more regular, the embryo implantation rate increased by 28%, and the young mice they gave birth to were healthier.

Wound healing: Accelerate "repair project"

Whether it is a small wound or postoperative healing, rapid cell division, collagen synthesis, and inflammation resolution are all required - all these processes rely on energy and cell repair capabilities.

NMN can press the "accelerator" for this "repair project" by increasing the level of NAD+.

"repair" mechanism of NMN

• Accelerate cell proliferation: Wound healing requires rapid division of skin cells and fibroblasts to fill the wound.

NAD + is the "energy basis" for cell division. After NMN supplementation, the speed of cell division accelerates, just like there are more workers in the "repair team".

• Reduce inflammatory interference: There will be an inflammatory response in the early stage of a wound, but excessive inflammation can delay healing.

Nmn-activated SIRT1 can inhibit excessive inflammation and keep the "repair project" undisturbed.

• Promote collagen synthesis: Collagen is the "building material" for wound healing.

NMN can promote the synthesis of collagen by fibroblasts, making wounds heal more firmly and less likely to leave scars.

Research evidence: Wounds heal 30% faster

In the mouse wound experiment, the wound healing time of mice supplemented with NMN was 30% shorter than that of the control group.

Sectional observation revealed that the number of fibroblasts at the wound site was greater, the collagen was arranged more neatly, and the levels of inflammatory factors (such as TNF-α) were also lower.

For humans, a small-scale study in 2022 showed that supplementing NMN (250mg/day) to postoperative patients shortened the average time for wound redness and swelling by 2 days, and NMN accelerates wound healing in the human body.

Tag: NMN , NAD

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