Five scientifically proven effective anti-aging substances - Knowledge

Five scientifically proven effective anti-aging substances

Jul 22, 2025 / Author: China Glutathione suppliers & NMN manufacturers

With the advent of the era of great health, more and more people have realized that what can be done about diseases by treatment alone is negligible, and the concept of preventing diseases before they occur has quietly emerged.

Aging is the trigger of many diseases, and anti-aging has become the mainstream health investment for many highly educated people.

Five scientifically proven effective anti-aging substances

The topic of "preventive anti-aging" on various platforms has received over 10 billion views, and public hospitals have successively set up anti-aging clinics.

Anti-aging is no longer the exclusive domain of celebrities, and various methods keep emerging. As ordinary people, how can we effectively resist aging?

5 Scientifically Proven Effective Anti-aging Ingredients!

NAD⁺ : "Energy engine" and repair Switch of cells

NAD⁺ (nicotinamide adenine dinucleotide) serves as a "cofactor" for thousands of enzymes in the human body, directly participating in the metabolism of sugars, fats, and proteins (such as the tricarboxylic acid cycle and oxidative phosphorylation), and providing energy for cells.

It serves as the "activation key" for crucial enzymes such as SIRT1 and PARP - SIRT1 is responsible for regulating gene expression, suppressing inflammation, and repairing DNA damage, while PARP dominates the repair of DNA breaks.

During the aging process, the level of NAD⁺ gradually decreases with age (possibly related to increased consumption and reduced synthesis), leading to insufficient cellular energy and a decline in repair capacity.

Supplementing NAD+ can activate enzymes related to anti-aging, maintain mitochondrial function, promote cell repair and metabolism, and delay aging.

Supplementation method: It is difficult to supplement by itself. Generally, its precursors (such as NMN, NR) can be supplemented, which can be converted into NAD⁺ to indirectly restore the vitality of this "engine".

NAD metabolism: Role in senescence regulation and aging

NMN: "Precise Supply Station" of NAD⁺

NMN (Nicotinamide Mononucleotide) is one of the direct precursors of NAD⁺. It has a small molecular weight and is easily absorbed. It can quickly pass through the cell membrane and enter the cell, and is catalyzed by "NMN adenylytransferase" to be converted into NAD⁺.

Animal experiments (such as on mice) have shown that supplementing NMN can increase the level of NAD⁺ in tissues (liver, muscle, brain), improve mitochondrial function, enhance insulin sensitivity, delay muscle atrophy, and partially reverse age-related cognitive decline.

Its advantage lies in its relatively high safety (no obvious side effects in short-term high doses in human trials), and thus it is regarded as the most promising "oral NAD⁺ supplementation regimen" at present.

Supplementation method: When 600 milligrams of NMN is taken orally daily, the clinical efficacy of NAD+ concentration in the blood and physical performance is the highest.

NAD+ Precursors Nicotinamide Mononucleotide(NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

Metformin: Multi-functional Anti-aging of "Metabolic Regulator"

As a classic hypoglycemic drug, the anti-aging mechanism of metformin leans more towards "global regulation" :

Activate the AMPK pathway

AMPK is the "energy sensing switch" of cells. It is activated when energy is insufficient (such as metabolic disorders caused by aging), which can inhibit mTOR (a pathway that promotes cell growth but accelerates aging) and promote autophagy (clearing damaged proteins and organelles), thereby delaying cell aging.

Inhibit mitochondrial ROS

By regulating the mitochondrial respiratory chain, it reduces the production of reactive oxygen species (free radicals) and lowers oxidative damage to DNA and proteins.

Intervention of intestinal flora

It is possible to improve metabolism and immune function by altering the composition of the intestinal flora and increasing the production of short-chain fatty acids (such as butyrate).

Supplementation method: Do not supplement by yourself. It should be used under the guidance of a doctor for "anti-aging indications".

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A recent study by a Chinese team in CELL shows that metformin can "systemically" improve the aging of primates, including the "rejuvenation" of 79 tissues and organs in 11 systems, especially with a significant ability to enhance cognitive ability and delay brain aging.

Coenzyme Q10: "Mitochondrial Shield" and free Radical Scavenger

Coenzyme Q10 (ubiquinone) is a core component of the mitochondrial electron transport chain, responsible for transferring electrons from complex I/II to complex III and promoting ATP synthesis.

As a liposoluble antioxidant, it can neutralize free radicals (such as superoxide anions) on the mitochondrial membrane, protecting the membrane structure and enzyme activity.

When aging, the decline in mitochondrial function leads to a reduction in the synthesis of coenzyme Q10.

Oral coenzyme Q10 supplementation

  • Enhance the energy metabolism efficiency of cells (especially in high-energy-consuming tissues such as the heart muscle and brain cells);

  • Reduce the damage to mitochondria caused by oxidative stress and delay the key aging marker of "mitochondrial aging".

  • It helps regulate blood pressure and improve degenerative problems related to energy metabolism such as migraines.

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an a-glucosidase inhibitor or a Nrf2- inducer

Stem cells: function of "cell regeneration bank" has been restarted

The essence of aging is the decline in tissue regeneration capacity - the number of stem cells decreases and their functions deteriorate, making it impossible to repair damaged cells in a timely manner.

Stem cell therapy combats aging in two ways:

Endogenous activation

Awaken dormant stem cells in the body (such as bone marrow mesenchymal stem cells) through drugs (such as growth factors and epigenetic regulators), and promote their proliferation and differentiation into tissue cells (such as cartilage and nerve cells).

Exogenous supplementation

Infusing stem cells from young individuals (or induced pluripotent stem cells) directly into atrophic tissues (such as joints, skin, and the blood system) to secrete growth factors (such as VEGF and FGF) to promote angiogenesis and cell repair, while regulating the immune microenvironment (inhibiting chronic inflammation).

Choose the corresponding nutritional supplements based on your own conditions to easily cope with aging.

However, anti-aging requires systematic and all-round management, including diet, exercise, sleep and psychological adjustment, etc. In the future, anti-aging may move towards "precise combination intervention", customizing plans based on individual aging markers (such as metabolic levels, inflammatory states, and stem cell activity).

Tag: aging, nmn

Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers

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