Research proves that NMN may improve obesity and related metabolic abnormalities - News

Research proves that NMN may improve obesity and related metabolic abnormalities

May 08, 2023 / Author: China Glutathione suppliers & NMN manufacturers

With the rapid economic and social development, people's diet structure and lifestyle have also changed. From 1975 to 2016, the proportion of adults with a body mass index > 25 increased to about 39% and 39% of men and women, respectively. 40%. In 2020, the number of obese people in the world will reach 1.211 billion, an increase of 58 million people compared with 2019, and a year-on-year increase of 5.04%.

Compared with people with normal weight, the risk of developing four major chronic diseases [cardiovascular disease, malignant tumor, chronic obstructive pulmonary disease (COPD for short), and type 2 diabetes] in the next 10 years increased by 26% for overweight people and obese people. % and 59%. Prevention and intervention of overweight and obesity is the most cost-effective measure to maintain health.

Many studies have reported that exogenous supplementation of Nicotinamide Mononucleotide (NMN) can improve the body's metabolic function and improve obesity and related symptoms of metabolic disorders.

NMN is a naturally occurring vitamin B derivative that is structurally composed of a nicotinamide group, a ribose sugar, and a phosphate group. NMN is the precursor substance for the synthesis of NAD+, one of the most common metabolites in the human body, and is important for various physiological processes such as energy metabolism in cells, DNA damage repair, epigenetic modification, inflammatory response, and oxidative stress.


During aging, obesity and related pathological processes, the body's NAD+ content decreases, which can easily lead to insulin resistance and chronic inflammation in multiple organs, which is closely related to the development of various metabolic diseases. Exogenous NMN supplementation can significantly increase the NAD+ content of various tissues and organs such as pancreas, liver, adipose tissue, skeletal muscle, heart, kidney, brain, and eye, and improve the symptoms of aging and obesity-related metabolic disorders.

A foreign study in 2017 proved that exercise can increase the body's NAD+ content, promote mitochondrial biosynthesis, and improve obesity and related metabolic abnormalities. Compared with exercise, intraperitoneal injection of NMN to obese mice fed a high-fat diet can also increase the oxidative metabolism of mitochondria and improve the glucose tolerance of mice; at the same time, supplementing NMN can increase the NAD+ content of mouse muscle and liver , improve obesity, aging and diabetes caused by high-fat diet.


Improvement of hepatic fat metabolism by NMN supplementation and exercise became important factors for overall improvement in obesity.

*Disclaimer: The content of this article is only for information and cannot replace the doctor's treatment diagnosis and advice. Always consult your healthcare provider for a diagnosis, accurate medical information, and clearance before taking any supplement.

Tag: nmn , obesity

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