Nov 11, 2022 / Author: China Glutathione suppliers & NMN manufacturers
The researchers found that NAD+ precursor NMN inhibited mast cell degranulation in mice and humans, and that intraperitoneal administration significantly reduced mast cell-related allergic reactions in mice.
Nicotinamide adenine dinucleotide + precursor may serve as an effective therapeutic strategy to limit mast cell-mediated allergic responses.
The successful generation of hCBMCs was confirmed by flow cytometry analysis of tryptase, FcεRI and CD117 (Fig. 2a). These cells were primed with myeloma IgE and activated + precursor with anti-IgE in the presence or absence of NAD.
NMN or NR pretreatment inhibited the release of β-hexosaminidase and the surface expression of CD63.
Taken together, these results demonstrate that NAD+ precursors effectively inhibit Ag-stimulated FcεRI signaling and mast cell degranulation in mouse and human mast cells in vitro.
This study demonstrates that cellular NAD+ levels are reduced due to allergic responses, and that treatment by NAD+ precursor NMN/NR significantly inhibits IgE-mediated mast cell degranulation and allergic responses, and helps to ameliorate allergic-induced inflammatory responses. And confirmed that the regulatory mechanism of allergy is closely related to Sirt6.
As a new generation, the highest level of dietary supplements, NMN provides energy to cells from the source, repairs damaged DNA, delays aging, and can significantly improve sleep, replenish physical and brain power, improve memory and cognition, enhance immunity, and improve energy and physical strength. .
It should be noted that NMN is an endogenous substance in the human body, but the trace amount of NMN in food is far from meeting the needs of the human body. For example, vegetables edamame and broccoli, which contain a lot of NMN in the daily diet, only contain less than 100g on average. 1mg of NMN, the high-content fruit avocado is only about 100mg per 20 kilograms, and the amount of NMN synthesized in an adult body every day is equivalent to several thousand kilograms of avocado.
Therefore, supplementing NMN dietary supplements to increase the NMN content in the human body has become a more effective and efficient way.
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers