Sep 23, 2022 / Author: China Glutathione suppliers & NMN manufacturers
Recently, researchers from Hyogo Medical University in Japan published an article in "Cureus". Through human clinical trials, they found that intravenous injection of NMN can not only increase the level of NAD+, but also significantly reduce the level of triglycerides, and it is also safe in terms of safety. Pretty reliable.
The researchers recruited 5 men and 5 women of different ages (20-70 years old), fasted them for 12 hours, and then injected 300 mg of NMN solution intravenously at 0.5, 1, 2, 3, and 30 days before and after NMN injection. For 5 hours, biochemical indicators such as body temperature, blood pressure, pulse, and oxygen saturation were measured.
The results showed that before and after intravenous injection of NMN, the subjects' urinalysis, electrocardiogram and chest X-ray were all normal, and there were no significant differences in body weight, body temperature, systolic blood pressure, diastolic blood pressure, pulse and oxygen saturation.
Clinical characteristics of healthy individuals before and after intravenous injection of NMN
Urinalysis of healthy individuals before and after intravenous NMN administration
Since the drug is administered intravenously rather than orally, the drug reaches organs throughout the body quickly and may be a burden on some organs. In order to verify the safety of intravenous NMN, the researchers also measured the levels of liver, pancreas, heart and kidney-related metabolic markers and blood cell-related biochemical indicators. The results showed that these indicators did not change significantly after intravenous NMN, which also It shows that the security of NMN is very reliable.
The researchers measured blood cell and overall NAD+ levels after intravenous injection of NMN, and the results showed that compared with before injection, blood cell NAD+ levels increased within 0.5-3 hours after injection, of which 0-0.5 hours increased the fastest, and total NAD+ Levels have a similar trend. In addition, the researchers also observed a significant increase in NAMPT mRNA expression, implying that SIRT1 was activated, confirming the increase in NAD+ levels. The above evidence shows that intravenous injection of NMN is indeed effective and can rapidly increase NAD+ levels.
At the same time, the researchers also tested blood lipid-related indicators and found that there was no significant difference in LDL, HDL and total cholesterol levels, but triglyceride (TG) levels decreased significantly from 0.1 to 5 hours after injection, although they increased after 3 hours. , but compared with before injection, it was still significantly decreased, which also confirmed the blood lipid lowering effect of intravenous injection of NMN.
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