NMN Fully Restores PCOS-induced Metabolic Dysregulation

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women, characterized by hyperandrogenism, ovulatory disorders, and ovarian polycystic changes, especially in women of puberty and reproductive age, with an incidence of 5% to 10%. Polycystic ovary syndrome often causes metabolic disorders, including insulin resistance, obesity, and hepatic steatosis.

The treatment of polycystic ovary syndrome is quite difficult, and there are few treatment methods, usually choosing to suppress androgen that is too high. Recent studies have found that NAD+ levels in patients with polycystic ovary syndrome will be significantly reduced. Scientists speculate that NMN or Can treat polycystic ovary syndrome.

Recently, the University of New South Wales in Australia published a study in "Molecular Metabolism", confirming previous speculation, they found that NMN can completely restore the metabolic dysregulation caused by polycystic ovary syndrome. They gave female mice with polycystic ovary syndrome NMN for 8 weeks and found that the fasting insulin levels of the treated mice were almost close to those of normal mice, and hyperinsulinemia, obesity and liver lipid deposition were significantly improved. , while NAD+ levels in the muscles were also restored.

The researchers found that NAD+ levels in muscle were significantly reduced in a hyperandrogenized rodent model of PCOS, and that treatment with the NAD+ precursor NMN corrected this deficit. Restoration of NAD+ levels in muscle was accompanied by DHT treatment-induced improvements in a range of metabolic parameters, including hyperinsulinemia, obesity, and hepatic lipid deposition.

Since reduced fasting insulin levels in NMN-treated PCOS mice are associated with reduced obesity and hepatic steatosis, chronic androgen receptor signaling in muscle reduces NAD+ levels, resulting in decreased insulin sensitivity and compensatory hyperinsulinemia, This drives de novo lipogenesis and adipose tissue expansion in the liver. Therefore, correcting this NAD+ deficiency in muscle using NMN therapy could be used as a strategy to address the different metabolic syndromes observed during PCOS.

Metabolic dysregulation is a unique feature of PCOS, and studies have linked PCOS to defects in NAD+. This decline can be corrected by treatment with NMN, resulting in lower fasting insulin levels, reduced obesity, and reduced fatty liver disease. Given the ongoing clinical translation of NMN and the widespread use of other precursors such as NR, this work may represent a promising strategy for treating the metabolic signature of PCOS in women.

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