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Coenzyme Q10 levels in the human body decrease with age, and reduced levels of coenzyme Q10 affect mitochondrial oxidative phosphorylation, reduce cellular ATP production, and affect egg quality and egg fertilization. Coenzyme Q10, as a proton and electron carrier within the mitochondrial inner membrane, has bioenergetic effects and is also an endogenous lipophilic antioxidant, widely present in biological membranes, mainly involved in electron transport and oxidative phosphorylation in the mitochondrial respiratory chain, which can antioxidant, scavenge free radicals, improve ovarian reserve function, increase follicle number and improve egg quality.
Mitochondria have an extremely important physiological role as the main site of oxidative phosphorylation and energy production. Mitochondria are also involved in calcium ion storage and transport during oocyte and embryo formation and development, and mitochondrial damage can lead to abnormal egg fertilization. OS), which affects the formation of quality embryos. Mitochondrial gene abnormalities (number changes, mtDNA fragment deletions, mutations) can reduce intracellular energy production. It has been suggested that low ATP levels can activate the mammalian target of rapamycin (mTOR) signaling pathway in eggs, leading to abnormal activation, increased loss of primordial follicles, premature follicular failure, and progressive development of DOR.
Coenzyme Q10 has the advantages of scavenging free radicals, anti-apoptosis, stabilizing cell membranes, reducing OS, improving body immunity, etc. It is an important antioxidant and immune enhancer, an important component of the mitochondrial electron transport chain, playing an energy conversion agent and an obvious anti-lipid peroxidation effect. In clinical practice, it has anti-aging, anti-fatigue, anti-hypertensive and cardioprotective effects.
Coenzyme Q10 is mainly involved in electron transport and oxidative phosphorylation in the mitochondrial respiratory chain, producing ATP and enhancing the endogenous antioxidant system in cells by inhibiting lipid peroxidation and DNA oxidation.
Coenzyme Q10 has free radical scavenging effects. Coenzyme Q10 is the only naturally reproducible fat-soluble antioxidant in the body. Coenzyme Q10 can scavenge free radicals, reduce OS and improve mitochondrial dysfunction through the conversion of oxidized reduced structures.
Coenzyme Q10 has an inhibitory effect on apoptosis. Coenzyme Q10 can protect mitochondrial DNA, eliminate oxygen free radicals, reduce OS, prevent mitochondrial DNA mutation caused by peroxidative damage, maintain the integrity of mitochondrial respiratory chain, and reduce apoptosis; Coenzyme Q10 can improve the efficiency of mitochondrial ATP production, promote cell growth and metabolism, and delay apoptosis; Coenzyme Q10 can prevent the opening of mitochondrial osmotic conversion pathway by inhibiting Coenzyme Q10 can inhibit the activation of mitochondria-dependent apoptotic pathway by inhibiting the opening of mitochondrial osmotic transition pathway to prevent mitochondrial depolarization and play an anti-apoptotic role; Coenzyme Q10 can inhibit reactive oxygen species-related apoptotic pathway.
A randomized controlled study showed that coenzyme Q10 pretreatment significantly reduced the total amount of gonadotropins required to obtain an ovarian response, shortened the duration of stimulation, increased peak E2 levels and the number of eggs obtained, and significantly increased fertilization rates and the number of superior embryos. Compared with the control group, the incidence of cancelled cycles due to non-response to stimulation was significantly lower in the coenzyme Q10-treated group, the number of cancelled embryo transfers due to embryo developmental failure was significantly lower, and the number of cycles using frozen embryos was significantly higher. The clinical pregnancy and live birth rates after coenzyme Q10 treatment were higher than those of the control group.
Oct 20, 2023