Pure Glutathione Powder Whitening Ingredients

Glutathione is a low molecular weight thiol tripeptide that plays an important role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its anti-melanogenic properties has led to its use as a skin lightening agent. Glutathione exists in a reduced form (GSH) and an oxidized form (GSSG).

Glutathione is the main component of "whitening pills" and "whitening injections" that are common on the market. A large number of experiments have proved that whitening pills or whitening injections containing glutathione are really effective.

Three whitening mechanisms of glutathione:

1. Directly inhibit the activity of tyrosinase, and at the same time, it can sweep away a large number of oxidative free radicals, prevent free radicals from activating tyrosinase, and can also be hydrolyzed into cysteine, which interferes with the synthesis of melanin, thereby inhibiting the precipitation of melanin and conditioning the skin. Play a role in whitening and lightening spots.

2. Indirectly mediate the switching mechanism from eumelanin to pheomelanin: human skin melanin has two forms of eumelanin and pheomelanin. When the synthesis of eumelanin increases and the synthesis of pheomelanin decreases, the skin color becomes darker; otherwise, the skin becomes whiter and brighter. Glutathione shifts melanogenesis from eumelanin to pheomelanin synthesis through the reaction between thiols and dopaquinone.

3. Accelerate the metabolism of the intermediate products produced during the production of melanin, which has the effect of "drawing fire from the bottom of the pot" and preventing the production of melanin.

The three main routes of administration of glutathione for whitening are topical (topical), oral (capsules and sublingual/buccal tablets) and injection (intravenous and topical). Sublingual or oral routes may improve glutathione bioavailability more than oral tablets or capsules. Although intravenous glutathione offers higher therapeutic doses, enhancing its efficacy, it has a narrower margin of safety due to possible excess toxicity. Local injection of glutathione belongs to mesotherapy, which is mainly used to treat melasma.

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