Skin Care Efficacy And Role Of NMN

NMN is an inherent substance of the human body and can be converted into a very important coenzyme I (NAD+) in the human body. Because of its unique "anti-aging" ability, it has successfully stood out among thousands of enzymes. In 2013, David Sinclair, a tenured professor of genetics at Harvard University, found through experiments that NMN has the effect of prolonging the lifespan of mammals, and published this top scientific research result in the internationally renowned academic journal "Cell".

The skin is a barrier that isolates the body from the external environment. In addition to protecting the body from moisture loss and microbial infection, the skin also plays an important cosmetic role. Young and beautiful appearance may have an impact on people's social behavior. Aging starts at birth, and the skin is no exception. As a large organ of the human body, the skin will show obvious and visible signs of aging with age.

Mitochondria are a source of cellular energy In 2018, Dr. Bhupendra Singh and colleagues found that mitochondrial DNA depletion causes time-dependent skin wrinkles and hair loss in mice, which is reversed if the mutation is turned off. NAD is located in mitochondria. A core component of energy production, research has shown that NAD levels in the skin decrease with age, and that NAD declines disrupt mitochondrial function. Dr. Ana Gomes and colleagues showed that NAD levels in 2-year-old mice Returning to youthful normal levels (levels in 6-month-old mice) greatly reversed age-related impairment of mitochondrial function and mitochondrial burnout.

DNA damage refers to the physical (such as ultraviolet radiation or chemical (such as nitrite) pollution factors in the environment that cause changes in the DNA structure of cells in the body. However, with aging, the ability to repair DNA decreases, and the accumulation of DNA damage will lead to genome The stability is reduced, and eventually the skin will age and even lead to the occurrence of skin cancer.

The level of NAD in cells affects the repair capacity of DNA damage NAD is the only known substrate of the ribozyme poly ADP-ribose polymerase-1 (PARP-1) PARP-1 can be activated by ultraviolet radiation and plays an important role in DNA repair . and is involved in maintaining genome stability, PARP-1 does this by regulating the expression of inflammatory cytokines chemokines, adhesion molecules and inflammatory mediators related transcription factors, therefore, supplementation of the NAD precursor NMN prevents cancer formation and prevents DNA damage .

NMN can increase the level of NAD+ in the body, and NAD+ is a natural substance in the body that acts on the longevity gene Sirtuin through mitochondria, but it gradually decreases with age and loses its repair ability. Therefore, by supplementing NMN to increase the level of NAD+, the purpose of delaying the aging speed of cells is achieved.

In conclusion, supplementation of NAD precursor NMN can prevent cell aging, improve skin condition, increase NAD levels in cells and tissues to improve their longevity, and treat skin or epithelial cells to prevent skin aging.