NMN May Improve The Body's Ability To Suppress Tumors And Prolong Life

NK cells are the real killers of our immune system, capable of directly destroying virus-infected cells and cancer cells. However, in order to kill bad cells, NK cells need a lot of energy.

Without enough energy, NK cells are damaged, causing tumors to grow uncontrollably. Now, researchers at Shandong University may have found a way to restore that energy.

As reported in Hepatology, nicotinamide adenine dinucleotide (NAD+) precursor Nicotinamide Mononucleotide (NMN) enhances the antitumor ability of NK cells.

Guo and colleagues showed that NMN-treated NK cells extended the lifespan of mice mimicking liver cancer (hepatocellular carcinoma) by nearly 3-fold, while reducing tumor growth. In addition, they showed that NMN reduced tumor size in mice that mimicked skin cancer (melanoma).

To mimic liver cancer in mice, Guo and colleagues injected liver cancer cells into severely immunodeficient mice to induce tumor growth.

To add energy to NK cells and try NK cell-based cancer treatments, Chinese researchers supplemented NK cells with NMN. By injecting cancer mice with NMN-treated NK cells, the researchers found that tumor-bearing mice had significantly improved overall survival.

( Guo et al., 2022 | Hepatology ) NMN-treated NK cells prolong lifespan. Immunodeficient mice injected with hepatoma cells (black) lived longer when injected with NK cells (red) and when NK cells were treated with NMN (blue).

NAD+ is an important molecule that mediates the production of cellular energy (ATP). By treating NK cells with NMN, NAD+ levels are increased, thereby producing more cellular energy. With enough fuel, NK cells can kill tumor cells more efficiently and inhibit tumor growth.

( Guo et al., 2022 | Hepatology ) NMN-treated NK cells inhibit liver tumor growth. Immunodeficient mice injected with hepatoma cells (control) had less tumor growth (measured by fluorescent tumors) when injected with NK cells (mock NK-92), while tumors grew when NK cells were treated with NMN (NMN-treated NK) less -92).

In another cancer model, Guo and colleagues injected skin cancer cells under the skin of mice. The mice were then injected with NMN-treated NK cells, and their tumors were subsequently harvested for measurement. NMN-treated NK cells were found to reduce tumor size more effectively than untreated NK cells.

Taken together, these findings suggest that NMN-treated NK cells can more effectively inhibit tumor growth in a variety of cancers than untreated NK cells.

Tag: NMN

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