Interfering Effect of NMN on Metabolism of Aging Mice

In order to study the effect of NMN on the metabolic function of aging mice, Shanghai Jiao Tong University School of Public Medicine and Shanghai Center for Disease Control and Prevention Dang Guodong and others randomly divided 70 C57BL/6N male mice into 5 groups, and after different treatments, Perform energy metabolism test, glucose tolerance test and insulin sensitivity test.

The results show that:

Energy metabolism experiment:

Compared with the control group, the levels of VO2 and VCO2 at night in the progeria model group and the aging model group were significantly decreased; compared with the aging model group, the VO2 and VCO2 in the intervention group II were significantly increased at night (Figure A, B); compared with the control group , the aging model group and the intervention group II significantly increased the daytime and night RER levels (Figure C); compared with the control group, the activity of the mice at night was significantly reduced in the premature aging model group, the aging model group and the intervention II group, and was comparable to that in the premature aging group. Compared with the model group, the activity volume of the intervention group I was significantly increased, and compared with the aging model group, the activity volume of the intervention group II was significantly increased (Figure D); Compared with the aging model group, the level of EE in the intervention group II was significantly increased (Fig. E).

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Glucose Tolerance Test:

At 12 weeks after modeling, compared with the control group, the blood glucose level of the aging model group was significantly higher, and the blood glucose level of the intervention group II was lower than that of the aging model group, and slightly higher than that of the control group; among them, at 60 min At the time point, the blood glucose level of the aging model group was significantly higher than that of the control group, and that of the intervention group II was significantly lower than that of the aging model group (Figure A).

The results of AUC analysis (Figure B) showed that the aging model group and the intervention group II had impaired glucose tolerance, indicating that with the prolongation of modeling time, the aging was aggravated, resulting in impaired glucose tolerance of the mice; the AUC of the intervention group II was compared with The aging model group decreased by 13%, indicating that impaired glucose tolerance was improved.

Insulin tolerance:

The results of the insulin tolerance test showed that at the time points of 30 minutes and 120 minutes, the blood glucose level of the aging model group was significantly higher than that of the control group, and that of the intervention group II was significantly lower than that of the aging model group (Figure A). At the same time, the analysis results of AUC (Figure B) also showed that D-gal aging modeling led to decreased insulin sensitivity in mice in the premature aging model group, aging model group and intervention group II. improve.

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in conclusion:

The results of the study showed that giving aging mice a certain dose of NMN for 6 weeks and 12 weeks of continuous intervention had certain improvements in energy metabolism, glucose tolerance, insulin sensitivity, etc., indicating that NMN can improve aging to a certain extent. Metabolism levels in mice. At the same time, the intervention effect of NMN on mice with different aging degrees was compared, and it was found that the longer the NMN intervention time, the more significant the improvement effect on the metabolic capacity of aging mice.

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