The effect of glutathione supplementation on NAFLD

Non-alcoholic fatty liver disease (NAFLD), characterized by a buildup of fat in the liver that is not caused by alcohol consumption, affects up to 25 percent of Americans.

Yet for various reasons, many people are unwilling or unable to make comprehensive lifestyle changes. In this setting, supporting small, sustainable changes in lifestyle can still produce significant improvements, but additional treatments are often still needed to address the chronic damage of NAFLD. Glutathione, as a nutritional bioactive, has potential use in the management of NAFLD because it plays a key role in cellular antioxidant and detoxification systems.

The therapeutic value of intravenous glutathione in the treatment of acute poisoning and chronic liver disease has been clinically recognized. Recently, oral glutathione has been studied for the treatment of NAFLD.

Glutathione is an antioxidant that can be found in a variety of plants, including asparagus, avocado, spinach, okra, broccoli, cantaloupe, tomatoes, carrots, grapefruit, oranges, zucchini, strawberries, watermelon and many more Other fruits and vegetables. It is also highly concentrated in freshly cooked meats. However, food sources of glutathione only account for a small portion of the body's total glutathione levels, as most are synthesized endogenously by the body itself at the cellular level. In this case, the amino acid precursors of glutathione - glutamate, glycine and cysteine - must also be obtained in adequate amounts from the diet.

There has been controversy over whether oral glutathione supplementation translates into increased bioactive levels of glutathione in the body, with many believing that oral glutathione is not fully absorbed and therefore cannot be successfully utilized by the body's cells. However, in recent years, emerging research suggests that oral glutathione supplements, especially protein-bound forms, can actually have beneficial effects on the redox potential in cells, exerting the effects of glutathione supplements in the human body. , included in the treatment of NAFLD.

Tag: Glutathione GSH

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