NMN improves heart function and prevents heart failure

Studies have confirmed that cardiac dysfunction is closely related to cardiovascular disease. The heart is composed of cardiomyocytes, which contain a large number of mitochondria, which provide the energy needed for contraction and relaxation throughout a person's life. However, as cells age, nicotinamide dinucleotide (NAD+) levels decrease, ATP output and mitochondrial function decrease, and oxidative stress, DNA damage, and mitochondrial structural changes increase. On this basis, scientists believe that mitochondria are crucial to heart health, and the decline in their function is closely related to mitochondria.

1. NMN can help prevent osteoporosis

Some research results show that NMN may improve steroid-induced osteoporosis.

The researchers cultured bone marrow mesenchymal stem cells in vitro and found that high-concentration hormone stimulation would reduce the bone-forming ability of cells. After using NMN, the number and activity of bone-forming proteins increased significantly, and the bone-building ability was restored.

2. NMN improves heart function and prevents heart failure

Studies have shown that with age, the level of NAD+, an important protective factor in the human body, gradually decreases. NAD+ is of great significance to energy metabolism, myocardial protection, tissue regeneration and anti-aging. Based on this, scientists infer that by supplementing NAD+ precursors and increasing the NAD+ level in the body, it may be able to effectively improve the metabolic level of cardiomyocytes, improve the contractility of the heart, and effectively reduce the risk of heart failure.

A research team used genetic means to reduce the NAD+ level of the mouse model, causing cardiomyocyte mitochondrial metabolic dysfunction, and found that the experimental animals showed heart failure; then short-term supplementation of NAD+ precursor NMN to the experimental animals reduced the death rate of cardiomyocytes 50%, and finally increased the survival rate of experimental animals by more than 3 times.

When NAD+ ages, the level of NAD+, an important protective factor in the body, gradually decreases. NAD+ plays an important role in energy metabolism, myocardial protection, tissue regeneration, and anti-aging. The researchers speculate that by supplementing the NAD+ precursor NMN and increasing the NAD+ level in the body, it may be able to effectively improve the metabolic level of cardiomyocytes, enhance the ability of the heart to contract, and effectively reduce the risk of heart failure.

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